Org . On Cysteine and Cystine Peptides . Part V . l S - Trityl - and S - Diphenyl - methyl - cysteine and - cysteine Peptides
نویسندگان
چکیده
A new method for the preparation of S-trityl(i.e. triphenylmethyl) and S-diphenylmethyl-cysteines or -cysteine peptides involves treatment of cysteine or cysteine peptides with aralkylcarbinols in the presence of trifluoroacetic acid or hydrogen halides in acetic acid solution. The optimal conditions for the removal of these S-protecting aralkyl groups by trifluoroacetic acid or hydrogen halides in acetic acid solution under various conditions have been determined.
منابع مشابه
On cysteine and cystine peptides. 3. Synthesis of a fragment of insulin containing the intrachain disulfide bridge.
The application of methods developed mostly in this laboratory permitted the synthesis of the fully S,Nprotected heptapeptides N-carbobenzoxy-S-trityl-L-cysteinylS-diphenylmethylL cysteinyl-LalanylglycylLvalyl-S-trityl-L-cysteinyl-L-serine methyl ester (VIII, Figure 21, N-t-butyloxycarbonyl-S-trityl-L-cysteiny1-Sdiphenylmethyl-LcysteinylL-alanylglycyl-LvalylStrityl-L-cysteinyl-L-serine methyl e...
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